Peroxisome Proliferator-Activated Receptors γ and α Mediate in Vivo Regulation of Uncoupling Protein (UCP-1, UCP-2, UCP-3) Gene Expression
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چکیده
منابع مشابه
Regulation of skeletal muscle UCP-2 and UCP-3 gene expression by exercise and denervation.
The factors that regulate gene expression of uncoupling proteins 2 and 3 (UCP-2 and UCP-3) in skeletal muscle are poorly understood, but both genes are clearly responsive to the metabolic state of the organism. Therefore, we tested the hypothesis that denervation and acute and/or chronic exercise (factors that profoundly affect metabolism) would alter UCP-2 and UCP-3 gene expression. For the de...
متن کاملUCP-2 and UCP-3 Proteins Are Differentially Regulated in Pancreatic Beta-Cells
BACKGROUND Increased uncoupling protein-2 (UCP-2) expression has been associated with impaired insulin secretion, whereas UCP-3 protein levels are decreased in the skeleton muscle of type-2 diabetic subjects. In the present studies we hypothesize an opposing effect of glucose on the regulation of UCP-2 and UCP-3 in pancreatic islets. METHODOLOGY Dominant negative UCP-2 and wild type UCP-3 ade...
متن کاملFactors Regulating Uncoupling Protein-3 (UCP-3) Expression in Skeletal Muscle
Submit Manuscript | http://medcraveonline.com J Nutr Health Food Eng 2015, 3(1): 00101 Abbreviations: UCP: Uncoupling Proteins; PGC1-α: Peroxisome Proliferator-Activated Receptor Gamma Co-Activator 1 Alpha; PPARα; Peroxisome Proliferator-Activated Receptor Alpha; BAIBA: β-Aminoisobutyric Acid; ROS: Reactive Oxygen Species; FFA: Free Fatty Acids; ETC: Electron Transport Chain; ATP: Adenosine Tri...
متن کاملPerspectives on the biology of uncoupling protein (UCP) homologues.
In mammals, it is believed that a portion of tissue metabolic rate is driven by counteraction of uncoupling, in which the energetically inefficient process of proton leak acts to diminish the mitochondrial electrochemical membrane potential. It is proposed that specific proteins associated with the mitochondrion catalyse uncoupling, and the biology of such putative uncoupling proteins (UCPs) is...
متن کاملUCP-3 expression in skeletal muscle: effects of exercise, hypoxia, and AMP-activated protein kinase.
Uncoupling protein 3 (UCP-3), a member of the mitochondrial transporter superfamily, is expressed primarily in skeletal muscle where it may play a role in altering metabolic function under conditions of fuel depletion caused, for example, by fasting and exercise. Here, we show that treadmill running by rats rapidly (30 min) induces skeletal muscle UCP-3 mRNA expression (sevenfold after 200 min)...
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ژورنال
عنوان ژورنال: Endocrinology
سال: 1998
ISSN: 0013-7227,1945-7170
DOI: 10.1210/endo.139.12.6384